Registration Dossier
Registration Dossier
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EC number: 618-804-0 | CAS number: 919-94-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The dermal sensitisation potential of TAEE was assessed in a GLP-compliant murine local lymph node assay (Method B.42 of Commission Directive 2004/73/EEC). In this study, TAEE gave Stimulation Indices less than 3 when tested at concentrations of 100%, 50% or 25% v/v in acetone/olive oil (4:1). Alpha-hexylcinnamaldehyde (positive control substance) gave a Stimulation Index of greater than 3 when tested at 15% v/v in acetone/olive oil (4:1) (Harlan Laboratories Ltd, 2009e).
The results of this study demonstrate that TAEE is not a skin sensitiser.
Migrated from Short description of key information:
TAEE is not a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Respiratory tract sensitisation is not expected as the substance contains no structural alerts and since no positive human data are available.
Justification for classification or non-classification
Based on the available data, TAEE is considered to be not sensitising. In accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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