Carbamic acid, [(1S)-2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-, phenylmethyl ester, dihydrochloride

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

not specified

GLP compliance:

no

Test procedure:

burning time (test type not further specified)

Remarks:

or specified in description of method (migrated information)

Burning time:

23 - 28 s

Results:

- By flint (Cereisenfunken) or a burning match, the sample did not ignite in any of the 5 attempts.

- The sample was ignited in 5 attempts by a small gas flame. However, the flame was extinguished upon removal of the ignition source again.

- In the red-hot steel shell, the sample burned 23 to 28 seconds.

Interpretation of results:

other: not highly flammable

Conclusions:

Carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) can be considered as not highly flammable.

Executive summary:

No ignition of carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) was observed in the preliminary screening test according to EU method A.10.Therefore, carbamic acid [(1S)-,2-[(2-aminoethyl)amino]-1-[(4-ethoxyphenyl)methyl]ethyl]-,phenylmethyl ester, dihydrochloride (9Cl) is not to be considered as highly flammable. No further testing is required.

Reference 2

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.12 (Flammability (Contact with Water))

Deviations:

no

GLP compliance:

no

Remarks on result:

no reaction with water observed

RESULTS: - There was no evolution of gas in dangerous quantities (1 L/kg*h) detected
- The maximum gas evolution rate was 0.2 L/kg*h
- A self-ignition of the gases in contact with water has not been observed.

Interpretation of results:

other: does not emit flammable gases in contact with water

Conclusions:

In accordance with section 1 of REACH Annex XI, a study on flammability in contact with water does not need to be conducted as the substance does not emit flammable gases in contact with water. Based on the structure the substance does not contain metals or metalloids.

Executive summary:

The flammability of a substance on contact with water is determined following the methods N.5 (UN-Manual of testing) or A.12 (EU-method).

However, in accordance with section 1 of REACH Annex XI, a study on flammability in contact with water does not need to be conducted as the substance does not emit flammable gases in contact with water. Based on the structure the substance does not contain metals or metalloids.

Reference 3

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Description of key information

A) Flammability: not flammable solid
B) Contact with water: In accordance with section 1.5 of REACH Annex XI, the study does not need to be performed as no reactivity with water is expected due to the chemical structure.
C) Pyrophoric properties: In accordance with section 1.5 of REACH Annex XI, the study does not need to be performed as no pyrophoric properties are expected due to the chemical structure.

Key value for chemical safety assessment

Flammability:

non flammable

Justification for classification or non-classification

The substance is not readily combustible, has no pyrophoric property, and shows no flammability in contact with water; and hence no classification according to both Directive 67/548/EEC and GHS (Regulation EC 1272/2008).