2H-Indol-2-one, 1,3-dihydro-4-(2-hydroxyethyl)-

Guidance on Safe Use

First-aid measures

Ingestion:

Never attempt to induce  vomiting. Do not attempt to give any solid or liquid by mouth  if the exposed subject is unconscious or semi-conscious.

Wash out the mouth  with water.  If the exposed subject is fully conscious, give plenty of water to drink.

Obtain medical attention.

Inhalation:

Using appropriate personal protective equipment, move exposed subject to fresh  air. If breathing is difficult or ceases, ensure and  maintain               ventilation.  Give oxygen  as appropriate. The exposed subject should  be kept warm and  at rest.  Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss  of consciousness or other  adverse effects, which may be            delayed.

Skin Contact:

Using appropriate personal protective equipment, remove contaminated clothing and  flush exposed area with large  amounts of water.           Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eye Contact:

Wash immediately with clean  and  gently flowing water.  Continue for at least  15 minutes. Obtain medical attention.

Fire-fighting measures

Fire and Explosion Hazards      

 

This material  is non-combustible.

Dust clouds  are  potentially  highly sensitive to ignition from incendive electrostatic discharges.

Dust clouds  are  of very low sensitivity  to ignition from hot surfaces. No ignition or exotherm of a powder  layer observed up to 400 °C. Ignition of a dust  cloud produces a strong  dust  explosion.

High pressure between 8 and  10 bar is produced during a dust  explosion.

Suitable Extinguishing Media       No special requirements needed. Water  is recommended for fires involving packaging.

Special protective equipment and precautions for firefighters:

Since  toxic, corrosive or flammable vapours might be evolved  from fires involving this material, self contained breathing apparatus and  full               protective equipment are  recommended for firefighters. Move containers from the fire area if possible without increased personal risk.

If possible, contain  and  collect firefighting water for later disposal.

Specific Hazards arising from the Material: Toxic or corrosive thermal decomposition products are  expected when this material  is exposed to fire.

Accidental release measures

Personal Precautions                  

 Fence or cordon  the affected area and  do not allow individuals  to touch  or walk through  the spilled material  unless wearing  appropriate protective clothing. Avoid dust  generation.

 

Environmental Precautions       Prevent entry into waterways, sewers, surface drainage systems and  poorly ventilated areas. If spill is outdoors, cover with plastic  sheet to minimise  spreading or contact with rain.

Clean-up Methods                       Collect and  place  it in a suitable, properly  labelled container for recovery or disposal. Following removal  of spillage, wash  down spillage area with copious amounts of water only if waste water can  be directed to an on-site  waste water treatment system.

Decontamination Procedures      

No specific  decontamination or detoxification  procedures have  been identified for this material.

Consider use  of water,  detergent solutions, or other  soluble  solvents,  for clean-up and  decontamination operations.

Avoid decontamination with oxidizing agents such  as household bleach, which will release hazardous  hydrochloric acid vapours.

Handling and storage

General requirements

Avoid dispersion as a dust  cloud.

Depending upon  the scale of operation, use  of appropriate exhaust ventilation  is recommended to provide routine  control of fire and  explosion hazards during handling of this material.

Ignition controls:

Bond and  earth  (ground)  all plant and  equipment to ensure that no isolated conductors are present. Isolated conductors can  accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.

Consider earthing (grounding) personnel dealing  with dusty operations. An isolated (insulated) human body can  readily produce electrostatic discharges in excess of 50 mJ, but have  been recorded up to 100 mJ.

Minimise the use  of plastics when handling this material.

The maximum  surface temperature of enclosures potentially  exposed to this material  should  be the lower of the values obtained by taking 2/3 of    the minimum ignition temperature for a dust cloud or 75 K less  than  the minimum ignition temperature of the dust  layer, with a maximum                   temperature of 325 °C.

Protective systems:

Assess operations based upon  available dust  explosion information  to determine the suitability of preventive or protective systems as precautionary measures against possible dust  explosions. If prevention is not possible, consider protection by use  of containment, venting  or suppression of dust  handling equipment. Where explosion venting  is considered the most  appropriate method of protection, vent areas should  preferably be calculated based on the Kst rather  than  the St value. If nitrogen  purging  is considered as the protective system, it must  operate with an oxygen  level below the limiting oxygen  concentration.  The system should  include  an oxygen  monitoring and shut-down facility in the event  of excessive oxygen  being  detected.

At both ambient and  low humidity, this material  is of low conductivity.   Generation of electrostatic charge is considered likely to occur  even  when handled in an earthed (grounded) environment.

At ambient humidity, this material  has  a long charge relaxation time. Accumulation of electrostatic charge is considered likely to occur  even  when   handled in an earthed (grounded) environment. Under  these conditions, it is considered that this material  might present a very high risk of producing an electrostatic discharge.

At low humidity, this material  has  a very long charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur  even     when handled in an earthed (grounded) environment. Under  these conditions, it is considered that this material  might present a very high risk of producing an electrostatic discharge.

CONDITIONS FOR SAFE STORAGE

Keep  in tightly closed containers or packages away from moisture and  away from sources of ignition.

Avoid prolonged storage at elevated temperatures (greater than  room temperature, approximately

20 degrees C).

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

Not regulated in transport.

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

Not regulated in transport.

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering Controls

This material  has  been assigned to GlaxoSmithKline Occupational Hazard Category 1 with a hygiene guide  of >1000  - 5000  mcg/m3. An Exposure Control Approach (ECA) is established for operations involving this material  based upon  the OEL/Occupational Hazard Category and  the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more  information  about  how ECA's are  assigned and  how to interpret them.

Containment:

No special engineering controls  are  required.

Ventillation:

Local exhaust ventilation  (LEV) is recommended

Personal Protective Equipment

Eye Protection: Wear  approved safety  glasses with side  shields or cover goggles if eye contact is possible.

Gloves:

The selection of gloves  for a specific  activity must  be based on the material's properties and  on possible permeation and  degradation that may occur  under  the circumstances of use. Glove selection must  take  into account any solvents and  other  hazards present. Potential allergic reactions can  occur  with certain  glove materials (e.g.  Latex) and  therefore these should  be avoided. Care  must  be exercised if insufficient data  are  available    and  further guidance should  be sought from your local EHS department.

Respiarity protection:

If respiratory protective equipment (RPE) is used, the type of RPE  will depend upon  air concentrations present, required protection factor as well as    hazards, physical  properties and warning  properties of substances present. Follow local regulations for respirator use  in the workplace.

Other equipment  or procedures

Wear  appropriate clothing to avoid skin contact. An eye wash  station  should  be available

Stability and reactivity

Conditions to Avoid              

Avoid direct sunlight,  conditions that might generate heat  and  dispersion as a dust  cloud

Disposal considerations

Collect for recycling  or recovery if possible. The recommended method of disposal is incineration.

Wherever possible, disposal should  be in an on-site  licenced chemical incinerator, if allowed  by the incinerator licence or permit.   If no on-site    incinerator is available, dispose of material  in a licenced commercial chemical incinerator.

Regulatory Requirements            

Observe all local and  national  regulations when disposing of this material.