Registration Dossier
Registration Dossier
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EC number: 600-581-6 | CAS number: 1045809-53-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 21-22 degrees Celcius
- pH:
- 7.6-8.1
- Dissolved oxygen:
- 8.6-9.0
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Exposure of Daphnia magna to the test item gave an EC50 of >100 mg/L based on the average fresh measured test concentrations.
- Executive summary:
Introduction
A study was performed to assess the acute toxicity of the test item to Daphnia magna. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (April 2004) No. 202, "Daphnia sp., Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008.
Results
Analysis of the fresh test preparations at 0 and 24 hours showed measured test concentrations to range from 4.6 to 89 mg/L. There was no significant change in the measured concentrations of the old or expired test solutions at 24 and 48 hours and so the results are based on the average fresh measured test concentrations only.
Exposure of Daphnia magna to the test item gave an EC50 of >100 mg/L based on the average fresh measured test concentrations.
Reference
Description of key information
Exposure of Daphnia magna to the test item gave an EC50 of >100 mg/L based on the average fresh measured test concentrations.
Key value for chemical safety assessment
Additional information
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