.beta.-D-Ribofuranose, 5-deoxy-, 1,2,3-triacetate

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 October 2012 to 20 February 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Fully GLP compliant and in accordance with current test guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Acetylfuranoside

IUPAC Name:

Acetylfuranoside

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Name: Acetylfuranoside
Physical state: White crystalline powder
Batch number: 201203272009
Purity: 98.7%
Arrival date: 26 October 2013
Expiry date: 31 March 2013
Storage details: Room temperature (15 to 30°C)

Results and discussion

Boiling point

Boiling pt.:

> 198 - < 299 °C

Decomposition:

yes

Remarks on result:

other: Temp. not reported

Any other information on results incl. tables

The DSC was checked with an indium standard and gave a melting onset at 156.36°C with a normalised energy of -28.55 Jg^-1. As this was within the specification of 156.3 to 156.9°C and -27.85 to -29.05 Jg^-1, the instrument was considered to be fit for purpose.

An endotherm equating to a melting temperature and exotherm equating to decomposition were recorded for Acetylfuranoside. The melting endotherm was well defined so the onset and peak temperatures are appropriate. The decomposition was over a large temperature range so the left and right limits were recorded.

Sample 1:      Melting temperature, onset 65.89°C, peak temperature 68.20°C.
                      Boiling temperature, left and right limits, 201.74°C to 296.51°C

Sample 2:      Melting temperature, onset 66.00 °C, peak temperature 68.02 °C.
                       Boiling temperature, left and right limits, 195.19 °C to 301.63 °C

Mean melting temperature onset: 66°C.

Mean boiling temperature range: 198 to 299°C.

Applicant's summary and conclusion

Conclusions:

The mean boiling temperature range for Acetylfuranoside was established as 198 to 299°C.

Executive summary:

The boiling point of Acetylfuranoside was measured in accordance with EC Directive 92/69/EEC Method A2 and OECD Guideline 103. The boiling temperature range was established as 198 to 299°C.