Registration Dossier
Registration Dossier
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EC number: 618-990-3 | CAS number: 939961-06-5
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed guideline study but without GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: 88/302/EWG Teil C
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
- EC Number:
- 618-990-3
- Cas Number:
- 939961-06-5
- Molecular formula:
- C15H15N3O3xClH
- IUPAC Name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Due to the poor solubility of the test item no stock solution was prepared. The tested amounts were added directly to the vessel
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Source: domestic waste water treatment plant Frankfurt/Main-Sindlingen
not adapted to test item and reference substance
pre-treatment according to guideline
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20+-2 °C
- pH:
- 7.2 +- 0.2
- Nominal and measured concentrations:
- nominal: 500 mg/L and 1000 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- < 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 < 1000 mg/L
- Executive summary:
The test substance was tested for the toxicity to bacteria according to OECD guideline 209. An EC50 < 1000 mg/L was determined.
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