Registration Dossier
Registration Dossier
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EC number: 618-990-3 | CAS number: 939961-06-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
- EC Number:
- 618-990-3
- Cas Number:
- 939961-06-5
- Molecular formula:
- C15H15N3O3xClH
- IUPAC Name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
- Details on test material:
- purity : 95.4 % (contains about 4.6 % water)
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.7
- Temp.:
- 23 °C
- pH:
- ca. 2.1
Any other information on results incl. tables
determ. no. stock solution water test substance conc. test substance conc. Log Pow
[ml] [ml] in n-octanol phase [mg/l] in water phase [mg/l]
A1 10 20 38,6 5,4 0,85
A2 10 20 38,4 5,4 0,85
B1 20 20 40,9 7,8 0,72
B2 20 20 38,6 7,9 0,69
C1 40 20 40,9 12,4 0,52
C2 40 20 43,2 12,4 0,54
mean --- --- --- --- 0,70
Recovery rate: 94 - 100%
HPLC conditions:
Column : Synergi Polar RP, 250 mm x 4,6 mm ID, 4 μm
Eluent A : acetonitrile/water with 0,05mol/l tetrabutyl ammonium hydrogensulfate = 5/95
Applicant's summary and conclusion
- Conclusions:
- The Log Pow of the substance is 0.7 at 23 °C.
- Executive summary:
The partition coefficient n-octanol / water of the susbstance was determined according OECD guideline 107 (flask method), using HPLC for the analytical determination. Log Pow was found to be 0.7 at 23 °C.
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