Registration Dossier
Registration Dossier
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EC number: 616-212-7 | CAS number: 75330-75-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Lovastatin did not demonstrate genotoxic potential in the Ames
bacterial mutagenicity assay, an alkaline elution assay using rat or mouse
hepatocytes, a mutation assay in Chinese hamster cells, a chromosomal aberration
assay in hamster cells and an in vivo mouse micronucleus assay.
Computational toxicology summary was prepared by DEREK Nexus version 2.0.2 software, and the result for genotoxicity is negative.
Short description of key information:
Lovastatin did not demonstrate genotoxic potential in the Ames
bacterial mutagenicity assay, an alkaline elution assay using rat or mouse
hepatocytes, a mutation assay in Chinese hamster cells, a chromosomal aberration
assay in hamster cells and an in vivo mouse micronucleus assay
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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