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EC number: 608-945-6 | CAS number: 340-90-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 June 2015-18 August 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP-compliant study in accordance with EC A.6 and OECD 105.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
- EC Number:
- 608-945-6
- Cas Number:
- 340-90-9
- Molecular formula:
- C13H11NO6
- IUPAC Name:
- (2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name (as cited in study report): Phthalyl-L-Glu
- Appearance: white powder
- Storage conditions: room temperature
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 9.92 g/L
- Temp.:
- 20 °C
- pH:
- 2.3
- Details on results:
The concentration analysed after 24, 48 and 72 hours of stirring was 9.75 g/L, 9.91 g/L and 10.1 g/L, resp. The maximum difference of 3.5% meets the criterion of = 15% . The reported water solubility is the mean of the concentrations analysed at t=24, 48 and 72 h.
The pH of the aqueous samples was 2.3.
No test substance was detected in the pretreated sample from the blank water mixture.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
In a GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840 using the flask method, the water solubility of Phthalyl-L-Glu at 20°C has been determined as 9.92 g/L.
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