Registration Dossier
Registration Dossier
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EC number: 612-831-1 | CAS number: 61967-98-4
Endpoint summary
Administrative data
Description of key information
Rat: LD50 (m/f) > 2200 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 200 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No information on the "acute oral toxicity" of the Target Substance is available. However data on Similar Substance 01 has been taken into account for the assessment. More details about the substance similarity is reported in section 13.
The acute oral toxicity of the test substance was investigated in two groups of 3 male and 3 female rats according to EU B.1/OECD 401 guideline, given a limit dose of 2200 mg/kg bw as gavage. Clinical signs were discoloured feces for male and female rats and piloerection and smeared fur in the anogenital area in male animals. No mortality or gross pathological changes were reported.
In the second study the acute oral toxicity of the test substance was investigated according to OECD guideline 401 in two groups of 3 male and 3 female rats, given a limit dose of 5000 mg/kg bw as gavage. Clinical signs were black feces for male and female rats. No mortality or gross pathological changes were reported.
Justification for classification or non-classification
Based on the criteria defined by the EU and the CLP criteria, the test substance needs not to be labelled for acute oral toxicity because no death occurred in the highest dosing group of 2200 mg/kg bw in male and female animals that could be attributed to the test substance administration.
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