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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 May 2016 - 02 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(17alpha)-3-ethoxy-19-norpregna-3,5-dien-20-yn-17-ol
EC Number:
619-217-2
Cas Number:
96487-85-3
Molecular formula:
C22H30O2
IUPAC Name:
(17alpha)-3-ethoxy-19-norpregna-3,5-dien-20-yn-17-ol
Test material form:
solid: particulate/powder
Details on test material:
Appearance: off-white powder
Test item storage: at room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
182.8 °C
Decomposition:
yes
Decomp. temp.:
300 °C

Any other information on results incl. tables

TGA EXPERIMENT (PRELIMINARY TEST)

Significant decrease of weight from 300°C. 25% weight loss at 362°C and 70% weight loss at 445°C.

After the experiment, an orange molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test item.

 

DSC EXPERIMENT 1

An endothermic peak between 150°C and 200°C was observed. The extrapolated onset temperature of the peak was

183.226°C. The effect was most likely obtained due to melting of the test item. An endothermic peak followed by an exothermic peak between 300°C and 362°C was observed. The effect was due to reaction and/or decomposition of the test item. After the experiment, an orange molten residue remained in the sample container. 

DSC EXPERIMENT 2

Experiment 2 was performed to determine the duplicate melting temperature of the test item.

The extrapolated onset of the melting peak was 182.308°C. After the experiment, an off-white molten residue remained in the sample container. Based on visual observations, it can be concluded that the endothermic peak was due to melting of the test item.

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

 

Applicant's summary and conclusion

Conclusions:
The melting temperature of the substance was determined to be 182.8°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 182.8°C. During heating from 25°C reaction and/or decomposition of the substance started at 300°C.