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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11.07.2006 - 13.07.2006
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DS/EN ISO 14669
Deviations:
no
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-Fluorophenyl)-2-(4-fluorophenyl)oxirane
Cas Number:
88374-05-4
Molecular formula:
C14H10F2O
IUPAC Name:
2-(2-Fluorophenyl)-2-(4-fluorophenyl)oxirane
Details on test material:
- Name of test material (as cited in study report): fluorphenylepoxyethan
- Physical state: liquid

Sampling and analysis

Analytical monitoring:
yes
Details on sampling:
- Concentrations: (Water accomodated fraction (WAF)): 10, 26, 64, 160, 400 and 1000 ml WAF/l
- Sampling method: 2 x 50 ml of stock solution
- Sample storage conditions before analysis: Freezer at -20ºC

Test organisms

Test organisms (species):
other: Arcartia tonsa (DANA)
Details on test organisms:
TEST ORGANISM
- Common name: Marine copepod

Study design

Test type:
semi-static
Water media type:
saltwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
20 ±0.5 ˚C
pH:
7.8
Salinity:
32 ‰
Nominal and measured concentrations:
Stock solution made by 500 mg substance sissolved in 500 ml test media.
Nominal concentration: 1000 mg/l.
Substance was not fully dissolved, therfore a test was taken from the middle of the volumetric flask (water accomodated fraction = WAF)
Details on test conditions:
TEST SYSTEM
- Test vessel: 100 ml Pyrex glass beakers
- Fill volume: 25 ml test solution
- Renoval: After 24 h 25 ml test solution was added
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates):5
- No. of vessels per vehicle control (replicates): 6
Reference substance (positive control):
yes
Remarks:
3,5-dichlorophenol (3,5-DCP), CAS No. : 591-35-5

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
LC10
Effect conc.:
0.82 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
1.9 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
mortality
Results with reference substance (positive control):
- Results with reference substance valid? Yes
- Mortality: 50% at 1.57 mg/l

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
Mortality in controls < 10 %, oxygen saturation ≥ 4 mg/l, mortality with reference test within acceptable range, 0.34-1.68 mg/l %
Conclusions:
LC50(48 h) of fluorphenylepoxyethan, CAS No. 88374-05-4 is 1.90 mg/L for Arcartia tonsa