Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 930-915-9 | CAS number: 1318-02-1
Endpoint summary
Administrative data
Description of key information
Oral
In the two reliable studies neither mortality nor any signs of clinical poisoning were observed.
Inhalation
In the key study with crystalline aluminosilicate no signs of toxicity were observed up to 18.3 mg/l during the exposure or the fourteen day observation period.
In the supporting study in a type A zeolite, all of the compounds tested appeared to produce an increased incidence of pulmonary abnormalities such as areas of hemorrhage and atelectasis, but these effects were not attributed to specific substances (like type A zeolite). Further, generally their incidence was considered to be slight to moderate. At least, there was no mortality observed.
Also, as supporting information: An in-vitro alveolar macrophage assay (used for predicting the acute toxicity of nanomaterials) showed that the effects of the four types of zeolites were heterogeneous and comparatively low when compared to natural aluminosilicates such as bentonite or kaolin studied with the same experimental setup (s.a. IUCLID 7.9.4)
Dermal
In the only reliable study neither mortality nor any signs of clinical poisoning were observed.
Key value for chemical safety assessment
Additional information
Four synthetic zeolites were tested for their in vitro bioactivity with the well establish NR8383 alveolar macrophage test.
Overall, the effects of the four types of zeolites were heterogeneous and comparatively low when compared to natural aluminosilicates such as bentonite or kaolin studied with the same experimental setup. The microscopically visible fractions of all four synthetic zeolites were completely ingested by the macrophages.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
