Registration Dossier
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EC number: 604-582-2 | CAS number: 1472-93-1
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Temp.:
- 25 °C
- Vapour pressure:
- < 0.001 Pa
- Conclusions:
- The vapour pressure of the test material was assessed according to OECD Guideline 104 and determined to be less than 1.2 x 10-3 Pa at 25 ºC.
- Executive summary:
The vapour pressure of the test substance was determined to be 1.2 x 10-3 Pa at 25ºC using a vapour pressure balance, designed to be compatible with method A4 of commission regulation (EC) No 440/2008 of 30 May 2008 and method 104 of the OECD guidelines for testing of chemicals, 23 March 2006 (Harlan Laboratories Ltd, 2013).
Reference
No statistical analyses of the data were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Higher temperatures could not be used due to the melting temperature of the test item. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapor pressure at 25 ºC.
Run 7 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 47 °C (320.15 K) was chosen because this is the data point which gives the highest estimated vapor pressure at any given temperature when a slope of -1500 K is imposed upon it.
The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapor pressure on a wide range of samples using the vapor pressure balance method. Extrapolation to 25 °C gave a vapor pressure of 1.13 x 10-3 Pa which has been taken as a maximum for this material.
Description of key information
The vapour pressure of the test material was assessed according to OECD Guideline 104 and determined to be less than 1.2 x 10-3 Pa at 25 ºC.
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure of the test substance was determined to be 1.2 x 10-3 Pa at 25ºC using a vapour pressure balance, designed to be compatible with method A4 of commission regulation (EC) No 440/2008 of 30 May 2008 and method 104 of the OECD guidelines for testing of chemicals, 23 March 2006 (Harlan Laboratories Ltd, 2013).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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