3-ethoxyandrosta-3,5-dien-17-one

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 May 2016 - 02 May 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2008

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

3-ethoxyandrosta-3,5-dien-17-one

EC Number:

619-264-9

Cas Number:

972-46-3

Molecular formula:

C21H30O2

IUPAC Name:

3-ethoxyandrosta-3,5-dien-17-one

Test material form:

solid: particulate/powder

Details on test material:

Physical appearance: white crystalline powder
Test item storage: In refrigerator (2-8°C)

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

155.1 °C

Decomposition:

yes

Decomp. temp.:

300 °C

Any other information on results incl. tables

TGA EXPERIMENT (PRELIMINARY TEST)

Significant decrease of weight from 300°C. 25% weight loss at 408°C and 70% weight loss at 452°C.

After the experiment, an orange/brown molten residue remained in the sample container (original colour: white). The change of the colour indicated reaction and/or decomposition of the test item.

 

DSC EXPERIMENT 1

An endothermic peak between 125°C and 175°C was observed. The extrapolated onset temperature of the peak was 155.328°C. The effect was most likely obtained due to melting of the test item. An endothermic peak between 300°C and 400°C was observed. The effect was due to reaction and/or decomposition of the test item. After the experiment, an orange/brown molten residue remained in the sample container. 

DSC EXPERIMENT 2

To investigate the melting peak, Experiment 2 was stopped after the endothermic peak at 175°C. The extrapolated onset temperature of the melting peak was 154.893°C. After the experiment, a colourless molten residue remained in the sample container. Based on this, it was concluded that the endothermic peak was due to melting of the test item.

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

 

Applicant's summary and conclusion

Conclusions:

The melting temperature of the substance was determined to be 155.1°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 155.1°C. During heating from 25°C reaction and/or decomposition of the substance started at 300°C.