Alcohols, C12-15, ethoxylated

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE
Microsoft Excel, version 2016

2. MODEL (incl. version number)
FISH EC50 C/EO QSAR mass based toxic unit additivity

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.

5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.

6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF.

Qualifier:

according to guideline

Guideline:

other: REACH Guidance on QSARs and grouping of chemicals (R.6)

Principles of method if other than guideline:

QSAR mass based toxic unit additivity, see attached QMRF for details

GLP compliance:

no

Test organisms (species):

Pimephales promelas

Test type:

other: (Q)SAR

Water media type:

freshwater

Total exposure duration:

96 h

Reference substance (positive control):

not required

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

0.628 mg/L

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Description of key information

LC50 (96 h): 0.628 mg/L (C/EO QSAR mass based toxic unit additivity)

Additional information

The acute toxicity of Alcohols, C12-15, branched and linear, ethoxylated to fish was assessed in a weight of evidence approach based on the grouping of substances (category approach). The weight of evidence approach combined experimental data and data derived by substance specific QSAR calculations. The lethal concentrations (96-h LC50), determined for the substances of the AE category are in the range of 0.423 – 8.211 mg/L.

The assessment of the acute toxicity of Alcohols, C12-15, branched and linear

to fish is based on QSAR data derived from an AE specific QSAR model.QSAR models for alcohol ethoxylates were developed based on both, literature data (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006), and experimental results obtained for representative source substances. The descriptors used for the linear regression modelling are the number of carbon atoms in the main alkyl chain n (linear or branched) and the degree of ethoxylation m. Since the target substances are UVCBs, a toxic unit approach is applied: the toxicity of a composition is calculated as a weighted average of the results obtained for single C(n)EO(m) units.

For the assessment of acute toxicity of the target substance to fish a LC50 (96 h) of 0.628 mg/L was predicted.