Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-092-7 | CAS number: 36890-68-3
Endpoint summary
Administrative data
Description of key information
ε-Caprolactone, oligomeric reaction products with 2,2' oxydiethanol has been tested for skin irritation and eye irritation in rabbits in studies conducted to OECD Test Guidelines 404 and 405 respectively. The substance was not found to be irritating to the skin or the eyes and no classification in respect of these endpoints is required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The dermal irritation potential of ε-Caprolactone, oligomeric reaction products with 2,2' oxydiethanol (CAPA 304) was investigated in a study performed according to OECD guideline 404. 0.5 g test material was applied on the clipped skin of 3 New Zealand White male rabbits for 4 hours. Animals were observed at 30-60 minutes and at 24, 48 and 72 hours after patch removal for oedema and erythema. The mean scores calculated for each individual animal tested for erythema and oedema at 24, 48 and 72 hours was 0. No dermal irritation was observed.
Eye irritation
The eye irritation potential of ϵ-caprolactone, oligomeric reaction products with 2,2’-oxydiethanol (CAPA 304) was investigated in a study performed according to OECD guideline 405. 0.1 mL test material was instilled into the left eye of three New Zealand White rabbits. Animals were observed at 1, 24, 48 and 72 hours after dosing under a standard light source. The reactions in the conjunctiva (redness, chemosis and discharge), the iris and the cornea (opacity and area involved) were scored according to the Draize scale. No corneal or iridial effects were noted during the study. Very slight irritation of the conjunctiva and lacrimation was observed in 3 rabbits 1 hour after instillation. This effect disappeared after 24 hours. The calculated mean score for redness, discharge, chemosis, iris and corneal lesions for all animals at 24, 48 and 72h after treatments was 0.
Justification for classification or non-classification
The substance was found to be non-irritating to the skin in a study conducted according to OECD 404 and was non-irritating to the eyes in a study conducted according to OECD 405. Classification for skin or eye irritation is not required according to the criteria of the Annex VI of the Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
