Registration Dossier
Registration Dossier
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EC number: 479-330-6 | CAS number: 67226-45-3
Endpoint summary
Administrative data
Description of key information
Dossier Substance is corrosive and according to column 2 of Annexes VII and VIII of REACh, allowance is made for the waiving of acute oral toxicity testing if the substance is corrosive to the skin.
Supporting information for the major degradaton product is available:
a) oral route of administration: OECD TG 423: LD50 300-20000 mg/kg bw
b) dermal route of administration: OECD TG 402: LD50 >20000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 300 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The Dossier compound is corrosive to the skin and thus no testing should be performed according to the REACH information requirements. However, a GLP compliant OECD 423 study for the most critical degradation product provides useful addional information and is thus used as supporting study for this endpoint.
Justification for selection of acute toxicity – dermal endpoint
The Dossier compound is corrosive to the skin and thus no testing should be performed according to the REACH information requirements. However, a GLP compliant OECD 403 study for the most critical degradation product provides useful addional information and is thus used as supporting study for this endpoint.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
