Registration Dossier
Registration Dossier
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EC number: 467-320-4 | CAS number: -
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Emergency measure - Inhalation: Move to fresh air. Give oxygen or artificial respiration if
needed. Obtain medical attention.
Emergency measure - Eyes: Rinse immediately with plenty of water for at least 15
minutes. Keep eye wide open while rinsing. Obtain medical
attention.
Emergency measure - Skin: Take off contaminated clothing and shoes immediately. Wash
off immediately with plenty of water for at least 15
minutes. If skin irritation persists, call a physician.
Emergency measure - Ingestion: Obtain medical attention. Do not induce vomiting. Never give
anything by mouth to an unconscious person.
needed. Obtain medical attention.
Emergency measure - Eyes: Rinse immediately with plenty of water for at least 15
minutes. Keep eye wide open while rinsing. Obtain medical
attention.
Emergency measure - Skin: Take off contaminated clothing and shoes immediately. Wash
off immediately with plenty of water for at least 15
minutes. If skin irritation persists, call a physician.
Emergency measure - Ingestion: Obtain medical attention. Do not induce vomiting. Never give
anything by mouth to an unconscious person.
Fire-fighting measures
Recommended extinguishing agent: Dry chemical, water spray and foam.
Do NOT use water jet.
Product arising from burning: The substance is combustible and will burn if involved in
a fire, evolving noxious fumes (eg carbon and nitrogen
oxides and chlorine containing compounds).
Product determined by test: N
Protective equipment: Full protective clothing and self-contained breathing
apparatus must be worn.
Fight the fire from a safe distance or protected location.
Do NOT use water jet.
Product arising from burning: The substance is combustible and will burn if involved in
a fire, evolving noxious fumes (eg carbon and nitrogen
oxides and chlorine containing compounds).
Product determined by test: N
Protective equipment: Full protective clothing and self-contained breathing
apparatus must be worn.
Fight the fire from a safe distance or protected location.
Accidental release measures
Emergency measures in case of spillage: Personal Precautions:
Use personal protective equipment. Examples include tightly
fitting safety goggles, lab coat, and impervious gloves.
Wear respiratory protective clothing. Depending on the
nature of the spill (quantity and extent of spill)
additional protective clothing and equipment, such as self-
contained breathing apparatus, may be needed.
Environmental Precautions:
Prevent release to drain and waterways. Prevent release to
the environment.
Containment Methods:
Wet down any dust to prevent the generation of aerosols, if
appropriate. Cover with suitable material.
Cleanup Methods:
Spill prevention procedures and a spill response procedure
should be implemented. Contain and collect spillage and
place in a container for disposal according to local
regulations. Handle waste materials, including gloves,
protective clothing, contaminated spill cleanup material,
etc., as appropriate for chemically and pharmocologically
similar materials.
The material is bought in pre-subdivided, to meet batch size
requirements so 'No' subdivision of material occurs on
site. The bags are never opened unless in the glovebox
environment. Therefore any spills are contained in a
glovebox, and are cleaned up and transferred into a waste
bag for disposal.
Use personal protective equipment. Examples include tightly
fitting safety goggles, lab coat, and impervious gloves.
Wear respiratory protective clothing. Depending on the
nature of the spill (quantity and extent of spill)
additional protective clothing and equipment, such as self-
contained breathing apparatus, may be needed.
Environmental Precautions:
Prevent release to drain and waterways. Prevent release to
the environment.
Containment Methods:
Wet down any dust to prevent the generation of aerosols, if
appropriate. Cover with suitable material.
Cleanup Methods:
Spill prevention procedures and a spill response procedure
should be implemented. Contain and collect spillage and
place in a container for disposal according to local
regulations. Handle waste materials, including gloves,
protective clothing, contaminated spill cleanup material,
etc., as appropriate for chemically and pharmocologically
similar materials.
The material is bought in pre-subdivided, to meet batch size
requirements so 'No' subdivision of material occurs on
site. The bags are never opened unless in the glovebox
environment. Therefore any spills are contained in a
glovebox, and are cleaned up and transferred into a waste
bag for disposal.
Handling and storage
Handling: The substance should be stored, handled and used under
conditions of good industrial hygiene and in conformity with
any local regulations in order to avoid exposure.
Engineering controls are necessary to reduce exposure to the
substance.
When exposure cannot be prevented or adequately controlled
appropriate personal protective equipment should be worn.
Such protective equipment should conform to the appropriate
international or national standards as follows;
*Impervious Nitrile, rubber and latex gloves (EN 420, EN
374).
* Laboratory coat (EN 340) or coverall of low permeability
(EN 465/1149-1).
* Safety glasses with side-shields or face shields (EN 166).
Furthermore, when respiratory protective equipment has to be
used, it must be capable of adequately controlling
exposure, be suitable for the purpose, and conform to the
appropriate international or national standards (EN 136).
These measures should be regarded as a minimum.
The material is charged using a double, chambered glovebox.
The material is brought into the glovebox in sealed bags.
Within the glovebox the BMS 435736 is removed from the bags
and charged to the reactor. The glovebox is rinsed with
solvent after the charge is complete. The waste bags are
removed from the glovebox using a contained bag-out port.
The glovebox is fitted with HEPA filtered nitrogen. The
exhaust from the glovebox is also HEPA filtered and also
fitted with a carbon filter.
Storage: Store at room temerature in the original container (<25
Deg.C). Keep away from heat, sparks and flames.
Keep containers tightly closed when not in use.
Packaging of the substance and or preparation: Plastic bags are typically supplied in bags of 5 kg, with
occational bag up to 6 kg. The typical batch input volume is
31 kg so in general 5 bags will be packed into a single dru
m.
conditions of good industrial hygiene and in conformity with
any local regulations in order to avoid exposure.
Engineering controls are necessary to reduce exposure to the
substance.
When exposure cannot be prevented or adequately controlled
appropriate personal protective equipment should be worn.
Such protective equipment should conform to the appropriate
international or national standards as follows;
*Impervious Nitrile, rubber and latex gloves (EN 420, EN
374).
* Laboratory coat (EN 340) or coverall of low permeability
(EN 465/1149-1).
* Safety glasses with side-shields or face shields (EN 166).
Furthermore, when respiratory protective equipment has to be
used, it must be capable of adequately controlling
exposure, be suitable for the purpose, and conform to the
appropriate international or national standards (EN 136).
These measures should be regarded as a minimum.
The material is charged using a double, chambered glovebox.
The material is brought into the glovebox in sealed bags.
Within the glovebox the BMS 435736 is removed from the bags
and charged to the reactor. The glovebox is rinsed with
solvent after the charge is complete. The waste bags are
removed from the glovebox using a contained bag-out port.
The glovebox is fitted with HEPA filtered nitrogen. The
exhaust from the glovebox is also HEPA filtered and also
fitted with a carbon filter.
Storage: Store at room temerature in the original container (<25
Deg.C). Keep away from heat, sparks and flames.
Keep containers tightly closed when not in use.
Packaging of the substance and or preparation: Plastic bags are typically supplied in bags of 5 kg, with
occational bag up to 6 kg. The typical batch input volume is
31 kg so in general 5 bags will be packed into a single dru
m.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN 3077
Shipping information
- Proper shipping name and description:
- Environmentally hazardous substance, solid, n.o.s.
- Chemical name:
- Pyrimidine Derivative
- Labels:
- 9
Special provisions / remarks
- Special provisions:
- 274
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- UN 3077
Shipping information
- Proper shipping name and description:
- Environmentally hazardous substance, solid, n.o.s (Pyrimidine Derivative)
- Labels:
- 9
Special provisions / remarks
- Remarks:
- special provision 274
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- UN 3077
Shipping information
- Proper shipping name and description:
- Environmentally hazardous subbstance, solid, n.o.s. (Pyrimidine Derivative).
- Chemical name:
- Pyrimidine Derivative
- Labels:
- 9
Special provisions / remarks
- Remarks:
- Special Provision: A97 Avoid crushing the containers. In the event of a spillage, observe the warning labels on the container.
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Engineering controls in the form of downflow booths with
HEPA filtration will be provided during sampling, weighing
and subdividing. If exposure needs to be further controlled,
approved respiratory protection (EN 136) will be worn. For
manufacturing areas skin protection will be provided in the
form of coveralls of low permeability (EN 1149-1) along with
impervious nitrile, rubber and latex gloves (EN 420, EN
374). Chemical safety goggles (EN 166) will be worn if a
full-face respirator is not being worn.
HEPA filtration will be provided during sampling, weighing
and subdividing. If exposure needs to be further controlled,
approved respiratory protection (EN 136) will be worn. For
manufacturing areas skin protection will be provided in the
form of coveralls of low permeability (EN 1149-1) along with
impervious nitrile, rubber and latex gloves (EN 420, EN
374). Chemical safety goggles (EN 166) will be worn if a
full-face respirator is not being worn.
Stability and reactivity
Danger other than fire: Keep away from strong oxidising agents and strong acids.
Chemical reaction with water: None which is hazardous.
Dust explosion: Under normal conditions of use this material does not
present a significant explosion hazard. However, like most
organic compounds it is combustible and may form a dust
explosion if widely dispersed in air.
Dust explosion determined by test: N
Chemical reaction with water: None which is hazardous.
Dust explosion: Under normal conditions of use this material does not
present a significant explosion hazard. However, like most
organic compounds it is combustible and may form a dust
explosion if widely dispersed in air.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: Discharge to the environment will be minimal. Recovery from
minor spillages or accidental discharge is not economically
or technically feasible, and such waste material will be
disposed of by incineration. In principle, it may be
possible to recover larger spillages of uncontaminated
material for subsequent use.
Industry - Possibility of neutralisation: The notification tests have shown that the substance is
harmful by acute oral ingestion, a skin irritant and skin
sensitiser and dangerous for the environment. There are also
concerns over potential clastogenicity based on a positive
result in a chromosome aberration study.
No chemical treatment is practicable to neutralise the
hazardous health properties.
The dust hazard will be minimised by appropriate handling
and storage.
No chemical treatment is practicable to neutralise the
hazardous environmental properties.
Industry - Possibility of destruction: controlled discharge: Not recommended.
Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning
under controlled conditions at a licensed waste treatment
processor in accordance with local regulations. Stack gases
should be scrubbed, because noxious fumes (eg. carbon and
nitrogen oxides and chlorine containing compounds) could be
formed. A closed-cycle incinerator with scrubbers should be
employed. National and local regulations must be observed.
Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to
the sewage system or the aqueous environment.
Industry - Possibility of destruction - other: None.
Public at large - Possibility of recovery/recycling: Not applicable.
Public at large - Possibility of neutralisation: Not applicable.
Public at large - Possibility of destruction: controlled discharge: Not applicable.
Public at large - Possibility of destruction - incineration: Not applicable.
Public at large - Possibility of destruction - water purification: Not applicable.
Public at large - Possibility of destruction - others: None.
minor spillages or accidental discharge is not economically
or technically feasible, and such waste material will be
disposed of by incineration. In principle, it may be
possible to recover larger spillages of uncontaminated
material for subsequent use.
Industry - Possibility of neutralisation: The notification tests have shown that the substance is
harmful by acute oral ingestion, a skin irritant and skin
sensitiser and dangerous for the environment. There are also
concerns over potential clastogenicity based on a positive
result in a chromosome aberration study.
No chemical treatment is practicable to neutralise the
hazardous health properties.
The dust hazard will be minimised by appropriate handling
and storage.
No chemical treatment is practicable to neutralise the
hazardous environmental properties.
Industry - Possibility of destruction: controlled discharge: Not recommended.
Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning
under controlled conditions at a licensed waste treatment
processor in accordance with local regulations. Stack gases
should be scrubbed, because noxious fumes (eg. carbon and
nitrogen oxides and chlorine containing compounds) could be
formed. A closed-cycle incinerator with scrubbers should be
employed. National and local regulations must be observed.
Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to
the sewage system or the aqueous environment.
Industry - Possibility of destruction - other: None.
Public at large - Possibility of recovery/recycling: Not applicable.
Public at large - Possibility of neutralisation: Not applicable.
Public at large - Possibility of destruction: controlled discharge: Not applicable.
Public at large - Possibility of destruction - incineration: Not applicable.
Public at large - Possibility of destruction - water purification: Not applicable.
Public at large - Possibility of destruction - others: None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
