Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 452-540-5 | CAS number: -
Guidance on Safe Use
Administrative data
First-aid measures
artificial respiration if breathing has stopped. Keep the
affected person warm and at rest. Seek medical attention.
Emergency measure - Eyes: Promptly wash with copious quantities of water while lifting
the eye lids for a period of at least 15 minutes. Seek
medical attention.
Emergency measure - Skin: Promptly remove any contaminated clothing or footwear, and
flush the skin with copious amounts of soap and water for at
least 15 minutes. Seek medical attention.
Emergency measure - Ingestion: Never make an unconscious person vomit or drink fluids.
Rinse mouth and give plenty of water to drink. Seek medical
attention.
Fire-fighting measures
Product arising from burning: COx
Product determined by test: N
Protective equipment: Wear self-contained breathing apparatus and full body
protective equipment.
Accidental release measures
Control the generation of dust / vapours. Provide
ventilation and respiratory, skin and eye protection to
prevent over-exposure. Keep out of drains: prevent entry to
surface water, groundwater and soil. Vacuum (with HEPA-
filtered explosion proof equipment) or scoop spilled
material and place in a container.
Handling and storage
systems (i.e. technical hoods equipped with HEPA- filter),
with operators donning the following PPE:- nitrile gloves
and safety glasses.
Dispensing of Latanoprost Lactone (PNU-249590) is carried
out in designated technical hoods, under negative pressure
with operators donning the following PPE:- nitrile gloves
and safety glasses.
Charging of Latanoprost Lactone (PNU-249590) is carried out
using a SPAT ( Stainless Portable Addition Tank). Charging
units(i.e. closed system charging) are under a nitrogen
bleed with operators donning the following PPE:- nitrile
gloves, safety glasses and Gemini full face mask (i.e.
negative pressure respirator).
Laboratories
Latanoprost Lactone (PNU-249590) is sampled in a designated
sampling room under extract (laminar air flow), with
personnel wearing tyvek suit, nitrile gloves and Gemini full
face mask. Once sampled the product is then handled in
fumehoods/downflow booths only (i.e. under negative pressure
and equipped with HEPA filter). PPE consists of nitrile
gloves and safety glasses.
PPE Specifications
Gloves: 'N-Dex' 7005 P/Free Nitrile Gloves Complies with BS
EN374.
Eye Protection: Denver 'Roma' safety Spectacles,
polycarbonate lense BS EN166:1996 (EU Directive 89/686/EEC)
(CE Mark: Category 2)
Respirator: 'Gemini' full face respirator. Silicone rubber
mask. Complies with BS EN136. Standard Thread filter
connection to EN148-1
Under NO circumstances is open handling of Latanoprost
Lactone (PNU-249590) permitted or carried out!
Storage: Store at room temperature.
Packaging of the substance and or preparation: 5 gallon (ca. 19 liter) fiber drums lined with two
polyethylene bags which are individually tied (Approx. 10-15
kg are packaged per drum)
Transport information
Shippingopen allclose all
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
Shippingopen allclose all
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
Shippingopen allclose all
Special provisions / remarks
- Remarks:
- Transport: Not regulated.
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Stability and reactivity
Chemical reaction with water: Does not occur.
Dust explosion: Not likely.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of neutralisation: Not Applicable.
Industry - Possibility of destruction: controlled discharge: Not Applicable.
Industry - Possibility of destruction - incineration: 660 Incineration, not specified.
Industry - Possibility of destruction - water purification: Not Applicable.
Industry - Possibility of destruction - other: Not Applicable.
Public at large - Possibility of recovery/recycling: Not Applicable as the substance will not be available for
the public at large.
Public at large - Possibility of neutralisation: Not Applicable as the substance will not be available for
the public at large.
Public at large - Possibility of destruction: controlled discharge: Not Applicable as the substance will not be available for
the public at large.
Public at large - Possibility of destruction - incineration: Not Applicable as the substance will not be available for
the public at large.
Public at large - Possibility of destruction - water purification: Not Applicable as the substance will not be available for
the public at large.
Public at large - Possibility of destruction - others: Not Applicable as the substance will not be available for
the public at large.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
