Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 433-400-2 | CAS number: 4245-76-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of CA 2342 A (intermediate to CGA 293343) to activated sludge was determined in a 3-hours respiration inhibition test, according to GLP Guideline OECD 209, under aerobic conditions at room temperature (20 +/-2 ºC). The experiment was conducted in compliance with Good Laboratory Pratice (GLP) in, Procedures and Principles, March 1986, issued by the Federal Department of the interior and the Intercantonal Office for the Control of Medicaments,.
The test substance concentrations tested were 320, 100, 32 and 10 mg/l. The reference substance 3,5-Dichlorophenol was tested in concentrations of 32, 10 and 3.2 mg/l.
The test system consisted of activated sludge collected from a communal sewage treatment plant. 1.56 g/l sludge (dry weight) was used in a test volume of 100 ml.
The respiration rate of the activated sludge fed with a standard amount of synthetic sewage feed was measured (OXI DIGI 530 (SAV: 00 109)) after a contact time of 3 hours with the test substance. The reference substance 3,5-Dichlorophenol and a blank (synthetic sewage feed, inoculum and water) served as controls. An IC50 (3h) value for CA 2343 A of > 320 mg/l was calculated.
Key value for chemical safety assessment
Additional information
Guideline Test Type |
Species |
IC50(3h) |
Reference |
Reliability |
OECD 209 |
activated sludge of a communal sewage treatment plant |
> 320 mg/l |
Ciba-Geigy Ltd., Schnalke, P.; 1996 |
Reliable without restriction |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
