Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 427-820-5 | CAS number: 2701-50-0 1,2-METHYLEN-4,6-DIENACETAT
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
1,2-Methylen-4,6-dienacetate (ZK 5690) is an intermediate of the synthesis of cyproteronacetate (CAS 427-51-0) and structurally very closely related. Due to its predominantly apolar components the substance is lipophilic in accordance with a log Pow of 2.66.
Cellular membranes are therefore expected to be penetrated and a dermal as well as an oral resorption is anticipated. In analogy to cyproteronacetate a substantial resorption from the GI tract is expected (see public informations on Androcur ® , 1991).
The substance is expected to be completely excreted in form of metabolites by both the biliary and the renal pathway.
Metabolism in analogy to other endogenous steroid hormones will predominantly take place in the liver such as reduction of the A -ring and the keto-group, and hydroxylation such as 15-beta-hydroxylation of cyproteronacetate.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
