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EC number: 297-443-7 | CAS number: 93572-14-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on fish up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
The assessment was therefore based on studies conducted with the
structurally analogue substances Fatty acids, C16-18 and C18-unsatd.,
2-ethylhexyl esters (CAS 85049-37-2) and Fatty acids, C8-16,
2-ethylhexyl esters (CAS 135800-37-2), as part of a read across
approach, which is in accordance with Regulation (EC) No. 1907/2006,
Annex XI, 1.5. Further justification is given within the overall summary
chapter 6.1 and within the analogue justification section 13.
The acute toxicity of Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl
esters (CAS 85049-37-2) was tested in a study following OECD 203
(Richterich 2001). The test organisms (Danio rerio) were exposed to
nominal substance concentrations of 1000, 3000 and 10000 mg/L for 96
hours. Mortality or effects of intoxication were not observed during the
exposure period. Thus a LC50(96h) > 10000 mg/L was determined at test
termination. Comparable results were obtained in a short-term toxicity
study on the second read across substance Fatty acids, C8-16,
2-ethylhexyl esters (CAS 135800-37-2). The short-term toxicity study was
performed according to EU Method C.1 under GLP conditions (Wierich,
1998). The test was set up under semi-static conditions. The test fish
(Danio rerio) were exposed for 96 hours to nominal test concentrations
of 1000, 3000 and 10000 mg/L. No mortality was observed at any of the
tested concentrations and a LC50 (96h) > 10000 mg/L was determined at
test termination.
Thus, based on the above mentioned result, and due to the structural and
profile similarities of the substances, as are explained with in the
overall endpoint summary 6.1 it can be concluded that no toxicological
effects on fish are expected up to the limit of water solubility for
Fatty acids, soya, 2-ethylhexyl esters (CAS 93572-14-6).
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