Registration Dossier
Registration Dossier
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EC number: 293-411-1 | CAS number: 91079-24-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Structural analogues of the substance have been tested in bacterial reverse mutation assays (Ames test) which showed the substance(s) not to induce reverse mutation in Salmonella typhimurium or Escherichia coli, an in-vitro chromosome aberration test which showed the substance not to induce chromosomal aberrations; an assay for the induction of trifluorothymidine resistant mutants in mouse lymphoma L5178Y cells after in vitro treatment which was negative and an assay for the ability to induce micronuclei in Chinese hamster V79 cells following in vitro treatment which was negative.
REACH Regulation 1907/2006 (Annex VIII, 8.4 Column 2) states that appropriate in-vivo mutagenicity studies should be considered in those cases of a positive result in any of the in vitro genotoxicity studies. In vitro investigations with the substance were negative and in vivo studies are therefore regarded as inappropriate and not in line with current concerns regarding animal welfare and the use of animals in scientific experiments.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Non-classification is justified on the basis of negative findings in a number of in-vitro tests on the substance
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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