Registration Dossier
Registration Dossier
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EC number: 292-334-0 | CAS number: 90604-40-3
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The log octanol/water partition coefficients of constituents of Alcohols, C12-15, branched and linear are in the range 5.15-6.55 at 20°C and pH 7 (HPLC method)
Key value for chemical safety assessment
Additional information
The n-octanol/water partition coefficient has been measured for the constituents of Alcohols, C12-15, branched and linear with the use of an HPLC method in accordance with OECD 117 Test Guideline. Log Kow values in the range 5.15 - 6.55 at 20°C and pH 7 were obtained for the constituents. The result is considered to be reliable.
Although, a weighted average partition coefficient value of 5.81 at 20°C and pH 7 was obtained for the whole substance, partition coefficient for a multi-constituent or UVCB substance is not meaningful scientifically for the purpose of assessment of exposure or risk.
Exposure and risk are assessed on the basis of log Kow of the individual constituents. Dodecan-1-ol has a reported log Kow value of 5.13 (Hansch 1995); tetradecan-1-ol has a reported log Kow value of 6.03 (Burkhard 1985) and pentadecan-1-ol has a predicted log Kow value of 6.43 at 25°C.
Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:
As chain length increases, the free energy required for a molecule to dissolve becomes less favourable for larger molecules. The octanol-water partition coefficient increases with molecular weight because each additional -CH2- group makes the octanol phase more preferred over water in terms of relative solvation energy.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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