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EC number: 292-222-1 | CAS number: 90583-23-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Apr - 13 May 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Details on inoculum:
- 0.5 mL effluent of the STP Hochdahl added per liter mineral medium
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium
- Solubilising agent: none
- Test temperature: 20-25°C
TEST SYSTEM
- Test apparatus: incubation of test vessels on a shaker
- Test substance samples: 2
- Number of replicates / test substance sample : 2
- Number of control replicates: 4
- Number of reference replicates: 2
SAMPLING
- Sampling frequency: samples taken on day 0, 3. 7, 10, 14, 17, 21, 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Toxicity control: no - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- > 93 - < 99
- Sampling time:
- 28 d
- Results with reference substance:
- 98% after 28 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Dec 1995 -12 Jan 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 1996, 27th February, The Department of Health of the Government of the United Kingdom
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Sewage treatment plant Hochdahl (1mL/L culture solution)
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 2 mg/L
- Based on:
- act. ingr.
- Initial conc.:
- 5 mg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 20 ± 1 °C
- Continuous darkness: yes
SAMPLING
- Sampling frequency: Day 0, day 7, day 21 and day 28
- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90 - 100
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
Referenceopen allclose all
Biodegradation of test and reference substances based on DOC removal [%]:
| Day | Test substance Series 1 |
Test substance Series 2 |
Reference substance |
| 3 | 100 | 100 | 100 |
| 7 | 91 | 85 | 92 |
| 10 | 94 | 90 | 96 |
| 14 | 93 | 92 | 96 |
| 17 | 94 | 93 | 96 |
| 21 | 99 | 96 | 100 |
| 28 | 93 | 99 | 100 |
Description of key information
Readily biodegradable: 93-99% (28 days, non-adapted sewage, OECD 301E)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
One ready biodegradability test is available for C12-14AS Mg (CAS 90583-23-6). The study (BASF, 1992) was done according to OECD 301E guideline under GLP conditions. As inoculum, a non-adapted sewage from a predominately domestic plant was used. Biodegradation based on DOC removal reached between 93 and 99% and therefore the substance is considered to be readily biodegradable.
Moreover, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to structurally related substance: C12-14AS Na (CAS 85586-07-8) was conducted.
A supporting GLP study with CAS 85586-07-8 was performed according to OECD guideline 301 D (Werner 1996). Activated, non-adapted domestic sludge was used as inoculum. The biodegradation after 28 days reached >90% (based on O2 consumption).
It can be concluded that C12-14AS Mg (CAS 90583-23-6) is readily biodegradable according to OECD criteria.
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