Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-122-8 | CAS number: 90552-02-6
Endpoint summary
Administrative data
Description of key information
In a well-conducted OECD combined repeated dose and reproductive/developmental toxicity screening test (OECD TG 422) by oral gavage in rats no toxicity occurred up to the highest administered dose of 1000 mg/kg/day. The NOAEL was determined to 1000 mg/kg/day.
With regard to the low repeated dose oral toxicity and the characteristics of skin penetration and metabolism in the skin, the repeated dose dermal toxicity can be considered as low. The inhalation route is not of relevance due to the very low vapour pressure of the substances. Taken as a whole there are sufficient data available for the long-chain alkyl methacrylate esters for assessment purposes so for the sake of animal welfare it is not proposed to conduct further repeated dose studies.
Key value for chemical safety assessment
Additional information
In a well-conducted OECD combined repeated dose and reproductive/developmental toxicity screening test (OECD TG 422) by oral gavage in rats, no toxicity occurred up to the highest administered dose of 1000 mg/kg/day.
The NOAEL for the repeated dose toxicity by oral gavage was determined to 1000 mg/kg/day.
Supporting information: In an OECD guideline 408 90-day gavage study in Wistar rats with the C8 Ester 2-ethylhexyl methacrylate, including a recovery period of 28 days, signs of general systemic toxicity occurred in male as well as female rats at 360 mg/kg bw/day. The NOAEL was120 mg/kg bw/day in males and females.
There are no data available for repeated dose exposure by the dermal or inhalation route. With regard to the low repeated dose oral toxicity and the characteristics of skin penetration and metabolism in the skin, the repeated dose dermal toxicity can be considered as low. This skin absorption study indicates that the total amount of the ester dodecyl methacrylate that was absorbed during the time of exposure was 0.7 % (rat epidermis) and 0.26 % (rat whole skin) over 24 hours, respectively. Thus, toxic effects via the dermal route are unlikely. The inhalation route is not of relevance due to the very low vapour pressure of the substances. Taken as a whole there are sufficient data available for the long-chain alkyl methacrylate esters for assessment purposes so for the sake of animal welfare it is not proposed to conduct further repeated dose studies.
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- No classification required.
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
- No classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
