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EC number: 291-639-6 | CAS number: 90432-09-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48 h, Daphnia magna) > 37 mg/l (meas. (geom. mean); equivalent to 100 mg/l nominal concentration)
NOEC (48 h, Daphnia magna) ≥ 37 mg/L (meas. (geom. mean); equivalent to 100 mg/l nominal concentration)
Key value for chemical safety assessment
Additional information
The following data were obtained for Similar Substance 01. It is expected that the Target substance will present similar effect levels to daphnia. Justification for the use of the Read Across approach is provided in Section 13 of IUCLID.
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna, according to the OECD Guideline 202 (2004) and the EU method C.2 of the Regulation EC 440/2008. The study was performed using the concentration of 100 mg/L Similar Substance 01 (nominal). For the test concentration, 20 daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours, the immobilised daphnia were counted. The concentration showed no significant toxicity. Only 1 animal (5 %) was immobilised in the treatment which is not considered significant. None of the animals were immobilised in the blank control. Potassium dichromate was used as positive control in a current reference study to assure that the test conditions are reliable. At the beginning and at the end of the test, the content of the test item in the test solutions was determined using a photometer method. At the beginning of the test the measured concentration was 38 % of the nominal concentration and after 48 hours the measured test concentration was 37 % of the nominal concentration. Therefore, the determination of the biological results was based on the geometric mean of the measured concentrations.
Based on the results of this experimental study, the EC50 of the test item was found to be higher than 37 mg/l (meas. (geom. mean)) when exposed to Daphnia magna for 48 hours, which is equivalent to 100 mg/L nominal concentration.
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