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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-02-12 to 2018-02-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
2004
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< -2
Temp.:
20 °C
pH:
>= 5.3 - <= 5.4
Remarks on result:
other: below determination limit of the method
Conclusions:
The determined partition coefficient of test item at 20.0 ± 6 °C is log Pow <-2
Executive summary:

The n-octanol/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8 (440/2008/EEC). For the determination of the n‑octanol/water partition coefficient of the test item the shake-flask method was used. The main test was performed in water at three different ratios of n-octanol and water (1/1, 2/1 and 1/2).

The concentration of the test item in the water phase and in the n‑octanol phase was taken for the calculation of n‑octanol/water partition coefficient (Pow) and its decimal logarithm (log Pow). The determined partition coefficient log POW at 20.6 ± 1 °C is <-2

The pH values of the water phases after shaking were determined to be between 5.30 and 5.40.

Description of key information

The n-octanol/water partition coefficient of the test item was determined according to OECD guideline 107 and EC method A.8 (440/2008/EEC). For the determination of the n‑octanol/water partition coefficient of the test item the shake-flask method was used. The main test was performed in water at three different ratios of n-octanol and water (1/1, 2/1 and 1/2).

The concentration of the test item in the water phase and in the n‑octanol phase was taken for the calculation of n‑octanol/water partition coefficient (Pow) and its decimal logarithm (log Pow). The determined partition coefficient log Pow at 20.6 ± 1 °C is <-2. The pH values of the water phases after shaking were determined to be between 5.30 and 5.40.

Key value for chemical safety assessment

Log Kow (Log Pow):
-2
at the temperature of:
20.6 °C

Additional information