Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-515-8 | CAS number: 84929-31-7 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus limonum, Rutaceae.
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50>5000 mg/kg bw (standard acute method, limit test)
Acute dermal toxicity: LD50>10000 mg/kg bw (standard acute method, limit test)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Additional information
Acute oral toxicity was tested in a standard acute limit test, in which a single dose of lemon oil (5000 mg/kg bw) was administered by oral gavage to 10 male Sprague-Dawley rats. No mortality was observed up to 14 days after application, therefore the oral LD50 was established to be >5000 mg/kg bw.
Acute dermal toxicity was also tested in a standard acute limit test, in which 6 female New Zealand White rabbits were exposed to a single dose of lemon oil (10000 mg/kg bw) dermally on the abraded abdominal skin. Based on the absence of mortality, a dermal LD50 >10000 mg/kg bw was established.
Justification for classification or non-classification
Based on the available information, lemon oil has been shown to be of low acute toxicity when applied via the oral and dermal route. Therefore, the substance lemon oil does not need to be classified for acute toxicity according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS) and Annex VI of 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
