Registration Dossier
Registration Dossier
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EC number: 282-775-7 | CAS number: 84418-63-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects to fish up to the limit of water solubility (OECD 202), read across
Key value for chemical safety assessment
Additional information
Since no experimental studies investigating the short-term toxicity of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (UVCB, CAS 84418-63-3) to aquatic invertbrates are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Dipentaerythritol ester with fatty acids, C5 and C9iso (CAS 647028-25-9) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13. Both substances consists of the same alcohol component (dipentaerythritol) and a similar fatty acid chain lengths as the target substance (C9iso for the target substance compared to C5 and 9iso for the source substance).
The study with the read across substance Dipentaerythritol ester with fatty acids, C5 and C9iso was conducted under static conditions according to OECD 202 using Daphnia magna as test organism. A nominal concentration of 100 mg/L (prepared as WAF) was tested. Analytical monitoring showed that the measured test concentration was less than the limit of quantification. After 48 h no effects were observed. No mortality and no signs of intoxication were observed. Therefore, this study resulted in a 48 h EL50 of > 100 mg/L (nominal). The NOELR (48 h) was derived to be >= 100 mg/L (nominal).
Based on the available results from this structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3) will not exhibit short-term effects on aquatic invertebrates up to the limit of water solubility.
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