Registration Dossier
Registration Dossier
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EC number: 278-154-5 | CAS number: 75268-65-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 October 2015 to 10 October 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: FAT 40138/G TE
Lot: 52-54
Appearance: Yellow powder - Key result
- Water solubility:
- 89 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: The preliminary visual experiments showed that the water solubility of the test item is between 50 g/l and 100 g/l. Final result obtained as an average of 3 experiments = 89 g/l
- Conclusions:
- The water solubility of FAT 40138/G at a temperature of 20 °C was determined to be 89 g/l.
- Executive summary:
The water solubility of the test substance was investigated in a study conducted according to OECD Guideline 105 and EU Method A.6. Flask method was used for this purpose, while VIS-spectroscopy was used for the detection of the concentration of the test substance. Based on the findings of the study, the water solubility of the test substance at a temperature of 20 °C was determined to be 89 g/l.
Reference
The water solubility of the test item at a temperature of 20 °C based on the average of three experiments was determined to be 89 g/L.
The recovery of 100.8 % indicated a sufficient accuracy of the analytical method.
Table: Solubility of the test item –experiments A to D
Experiment |
A |
B |
C |
D (blank) |
Amount of test item (mg) |
2500 |
2500 |
2500 |
-- |
Stirring time at 30°C (h) |
24 |
48 |
72 |
72 |
Measured concentration (µg/ml) |
5.4 |
5.5 |
5.7 |
-- |
Dilution |
0.05ml/10ml/ 0.125 ml/10ml |
0.05ml/10ml/ 0.125 ml/10ml |
0.05ml/10ml/ 0.125 ml/10ml |
-- |
Solubility (g/l) |
86.4 |
88.7 |
91.6 |
-- |
Table: Concentrations of the standards for recheck:
Standard |
Measured concentration (µg/ml) |
% Recovery |
Solution C + 5.7 µg |
11.5 |
100.8 |
The recovery of 100.8 % indicates a sufficient accuracy of the analytical method.
Description of key information
The water solubility of the test substance was investigated in a study conducted according to OECD Guideline 105 and EU Method A.6. Flask method was used for this purpose, while VIS-spectroscopy was used for the detection of the concentration of the test substance. Based on the findings of the study, the water solubility of FAT 40138/G at a temperature of 20 °C was determined to be 89 g/l.
Key value for chemical safety assessment
- Water solubility:
- 89 g/L
- at the temperature of:
- 20 °C
Additional information
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