Registration Dossier
Registration Dossier
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EC number: 278-047-3 | CAS number: 74993-03-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-04-23
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The water solubility of the test substance was determed by stepwise addition of the test substance into water and visual inspection.
- GLP compliance:
- no
Test material
- Reference substance name:
- γ-methylaziridine-1-propylamine
- EC Number:
- 278-047-3
- EC Name:
- γ-methylaziridine-1-propylamine
- Cas Number:
- 74993-03-6
- Molecular formula:
- C6H14N2
- IUPAC Name:
- 3-(aziridin-1-yl)butan-1-amine
- Details on test material:
- - Name of test material (as cited in study report): C4-Amine
- Substance type: Mono constituent substance
Constituent 1
Results and discussion
- Details on results:
- The water solubility of test substance was determined to be ≥ 66.7 wt%.
Any other information on results incl. tables
Table 1. Step by step addition of test substance into 10 g water
Step |
amount of test substance added (g) |
total amount added (g) |
Concentration (wt%) |
visual observation |
Temperature rise |
1 |
1 |
1 |
9.1% |
clear, colorless solution |
from 22 to 24 |
2 |
2 |
3 |
23.1% |
clear, colorless solution |
from 23 to 26 |
3 |
4 |
7 |
41.2% |
clear, colorless solution |
from 25 to 32 |
4 |
13 |
20 |
66.7% |
clear, colorless solution |
from 31 to 45 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): miscible
The water solubility of test substance was determined to be ≥ 66.7 wt%. - Executive summary:
The water solubility of the test substance was determined by stepwise addition of the test substance into water and visual inspection. An amount of 1, 2, 4, and 13 g of test substance was added into the same Erlenmeyer-flask containing 10g water in
each step. The total amounts of the test substance after each addition were 1, 3, 7, and 20 g. A clear, colorless solution was obtained after each addition. The water solubility of test substance was determined to be ≥ 66.7 wt%.This study did not follow a guideline nor conducted under GLP. However, the test procedure meets generally accepted scientific principles and is acceptable for assessment.
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