Registration Dossier
Registration Dossier
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EC number: 277-955-7 | CAS number: 74664-50-9
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The complete read across justification is detailed in section 13. Test substance is an isomer of the substance under registration; structural difference is not expected to significantly impact adsorption/desorption. Source study has reliability 2: only limited information available from a migrated NONS file, as per Article 25(3) request.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
- Type:
- Koc
- Value:
- < 1.45
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Koc < 1.45
logKoc < -3 - Executive summary:
Method
The test has been conducted according to the OECD guideline 121. Information was derived from migrated NONS file, as per Article 25(3) request, with permission to refer granted by ECHA.
Results
Koc < 1.45
logKoc < -3.
Reference
The substance was not retained on the column. The log Koc was estimated to be < -3 by extrapolation.
Description of key information
Koc < 1.45
logKoc < -3.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.45
Additional information
Due to the lack of data on Direct Blue 273, a read across approach was followed, using Similar Substance 01, i.e. an isomer of Direct Blue 273, differing only for the position of a functional group on an aromatic ring. Further details on the read across approach are included in section 13.
The evaluation of the adsorption/desorption coefficient of Direct Blue 273 has been based on a study conducted on Similar Substance 01.
This study was conducted according to the OECD guideline 121, in compliance with GLP principles. Information derived from migrated NONS file, as per Article 25(3) request, with permission to refer granted by ECHA.
Test substance was not retained on the column and showed a Koc value < 1.45 (the log Koc was estimated < -3 by extrapolation).
Based on the structural similarity, Koc and logKoc values of Similar Substance 01 are expected to be representative also for Direct Blue 273.
[LogKoc: -3.0]
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