Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 265-048-9 | CAS number: 64741-48-6 A complex combination of hydrocarbons separated as a liquid from natural gas in a gas recycling plant by processes such as refrigeration or absorption. It consists mainly of saturated aliphatic hydrocarbons having carbon numbers in the range of C2 through C8.
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Worker DNELs for Low boiling point naphthas (gasolines)
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(b) |
|
|
Inhalation |
1300 mg/m3/15 min |
4320 mg/m3/1 h (LOAEC based on for neuromuscular symptoms in human volunteers) |
Dose descriptor was modified to correct starting point of 3859 mg/m3/15 min by adjustment for duration of exposure, LOAEC to NOAEC, and ventilation rate of workers. Then AF of 3 was applied for intraspecies differences. |
||
Local |
Dermal |
(c) |
|
|
|
Inhalation |
1100 mg/m3/15 min |
2400 mg/m3/1 h (LOAEC based on irritation of nose and throat in human volunteers) |
Dose descriptor was modified to correct starting point of 3200 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 3 was applied for intraspecies differences. |
||
Long-Term Exposure |
Systemic (a) |
Dermal |
(b) |
|
|
Inhalation |
(b) |
|
|
||
Local |
Dermal |
(c) |
|
|
|
Inhalation |
840 mg/m3/8h |
10,000 mg/m3/6 h (NOAEC based on red nasal discharge in rats exposed by inhalation for 6 h/day, 5 days/wk for 13 wk) |
Dose descriptor was modified to correct starting point of 5025 mg/m3/8-h day by adjustment for duration of daily exposures and ventilation rate of workers. Then AF of 6 was applied for inter- and intraspecies differences and for overall duration of exposure. |
a) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
b) No hazard identified for this route (data available)
c) The data do not allow setting a DNEL.
Worker DNELs for Low boiling point naphthas (gasolines) (R45/46; R62/63)
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(c) (a) |
|
|
Inhalation |
1300 mg/m3/15 min (a) |
4320 mg/m3/h (LOAEC based on for neuromuscular symptoms in human volunteers) |
Dose descriptor was modified to correct starting point of 3859 mg/m3/15 min by adjustment for duration of exposure, LOAEC to NOAEC, and ventilation rate of workers. Then AF of 3 was applied for intraspecies differences. |
||
Local |
Dermal |
(d) |
|
|
|
Inhalation |
1100 mg/m3/15 min |
2400 mg/m3/h (LOAEC based on irritation of nose and throat in human volunteers) |
Dose descriptor was modified to correct starting point of 3200 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 3 was applied for intraspecies differences. |
||
Long-Term Exposure |
Systemic (b) |
Dermal |
(c) (a) |
|
|
Inhalation |
(c) (a) |
|
|
||
Local |
Dermal |
(d) |
|
|
|
Inhalation |
840 mg/m3/8h |
10,000 mg/m3/6 h (NOAEC based on red nasal discharge in rats exposed by inhalation for 6 h/day, 5 days/wk for 13 wk) |
Dose descriptor was modified to correct starting point of 5025 mg/m3/8-h day by adjustment for duration of daily exposures and ventilation rate of workers. Then AF of 6 was applied for inter- and intraspecies differences and for overall duration of exposure. |
a) Additional consideration should be given to an inhalation DMEL-worker for benzene of 1 ppm if benzene air concentrations are sufficiently high. A dermal reference value for workers of 23.4 mg of benzene/kg/day [1% absorption of benzene from benzene-containing petroleum naphtha streams via the skin] should be considered if dermal exposure is expected.
b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
c) No hazard identified for this route (data available)
d) The data do not allow setting a DNEL.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General Population DNELs for Low boiling point naphthas (gasolines)
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic
|
Dermal |
(a) |
|
|
Inhalation |
1200 mg/m3/15 min |
4320 mg/m3/h (LOAEC based on for neuromuscular symptoms in human volunteers) |
Dose descriptor was modified to correct starting point of 5760 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 5 was applied for intraspecies differences. |
||
Local |
Dermal |
(e) |
|
|
|
Inhalation |
640 mg/m3/15 min |
2400 mg/m3/h (LOAEC based on irritation of nose and throat in human volunteers) |
Dose descriptor was modified to correct starting point of 3200 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 5 was applied for intraspecies differences. |
||
Long-Term Exposure |
Systemic (b) |
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Oral |
(d) |
|
|
||
Local |
Dermal |
(e) |
|
|
|
Inhalation |
180 mg/m3/24h |
10,000 mg/m3/6 h (NOAEC based on red nasal discharge in rats exposed by inhalation for 6 h/day, 5 days/wk for 13 wk) |
Dose descriptor was modified to correct starting point of 1785 mg/m3/24-h day by adjustment for duration of daily exposures and number of exposures per week. Then AF of 10 was applied for inter- and intraspecies differences and for overall duration of exposure. |
a) No hazard identified for this route (data available)
b) Long-term systemic effects include developmental/reproductive effects. Lowest DNEL is shown.
c) A DNEL for short-term oral exposures of the general population was not calculated for the reasons given below.
a) Acute oral toxicity studies with gasoline or naphtha streams did not result in significant adverse effects with doses at or above the limit dose.
b) Oral contact with gasoline and naphtha streams should be avoided because of the aspiration hazard. Gasoline and naphtha streams are labelled R65 (Harmful, may cause lung damage if swallowed).
d) A DNEL for long-term oral exposures of the general population was not calculated for the reasons given below. The hazard from long-term oral exposures of the general population may be more dependent on the presence of benzene or toluene in gasoline; appropriate measures should be taken based on the levels of those substances.
a) Dermal or inhalation repeat-dose studies with gasoline or naphtha streams did not result in adverse systemic effects with doses at or above the limit dose.
b) Aside from potential neuromuscular effects from very high doses, acute exposures to gasoline and naphtha streams also have not resulted in significant adverse systemic effects.
c) Data on oral exposures were not available (possibly because it was not considered to be a relevant route).
e) The data do not allow setting a DNEL.
General Population DNELs for Low boiling point naphthas (gasolines) (R45/46; R62/63)
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic
|
Dermal |
(a)(c) |
|
|
Inhalation |
1200 mg/m3/15 min (a) |
4320 mg/m3/h (LOAEC based on for neuromuscular symptoms in human volunteers) |
Dose descriptor was modified to correct starting point of 5760 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 5 was applied for intraspecies differences. |
||
Local |
Dermal |
(e) |
|
|
|
Inhalation |
640 mg/m3/15 min |
2400 mg/m3/h (LOAEC based on irritation of nose and throat in human volunteers) |
Dose descriptor was modified to correct starting point of 3200 mg/m3/15 min by adjustment for duration of exposure and LOAEC to NOAEC. Then AF of 5 was applied for intraspecies differences. |
||
Long-Term Exposure |
Systemic (b) |
Dermal |
(a)(c) |
|
|
Inhalation |
(a) (c) |
|
|
||
Oral |
(a) (d) |
|
|
||
Local |
Dermal |
(e) |
|
|
|
Inhalation |
180 mg/m3/24h |
10,000 mg/m3/6 h (NOAEC based on red nasal discharge in rats exposed by inhalation for 6 h/day, 5 days/wk for 13 wk) |
Dose descriptor was modified to correct starting point of 1785 mg/m3/24-h day by adjustment for duration of daily exposures and number of exposures per week. Then AF of 10 was applied for inter- and intraspecies differences and for overall duration of exposure. |
a) Additional consideration should be given to an inhalation DMEL-general population for benzene of 1 ppb if benzene air concentrations are sufficiently high. Using this air concentration reference value for benzene in air of 1 ppb (3.5 microgram/m3) and assuming a default inhalation rate of 20 m3/day and a body weight of 70 kg yields a reference value for indirect exposure of 1.0 microgram benzene/kg/d. The ratio of benzene to total gasoline vapor utilized was 0.01. Thus, the resulting reference value utilized for indirect exposure of man via the environment is 100 micrograms total naphtha hydrocarbon containing benzene /kg/d (see CSR Section 10). A dermal reference value for general population of 23.4 micrograms of benzene/kg/day [1% absorption of benzene from benzene-containing petroleum naphtha streams via the skin], should be considered if dermal exposure is expected. An oral reference value for general population, of 0.234 micrograms of benzene/kg/day, from benzene-containing petroleum naphtha streams in the environment should be considered if exposure via the oral route is expected (this is not expected).
b) Long-term systemic effects include developmental/reproductive effects. Lowest DNEL is shown.
c) No hazard identified for this route (data available)
d) A DNEL for long-term oral exposures of the general population was not calculated for the reasons given below. The hazard from long-term oral exposures of the general population may be more dependent on the presence of benzene or toluene in gasoline; appropriate measures should be taken based on the levels of those substances.
c) Dermal or inhalation repeat-dose studies with gasoline or naphtha streams did not result in adverse systemic effects with doses at or above the limit dose.
d) Aside from potential neuromuscular effects from very high doses, acute exposures to gasoline and naphtha streams also have not resulted in significant adverse systemic effects.
d) Data on oral exposures were not available (possibly because it was not considered to be a relevant route).
e) The data do not allow setting a DNEL.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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