Registration Dossier
Registration Dossier
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EC number: 256-260-2 | CAS number: 46235-93-2
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- Justification for type of information:
- 60% degradation was observed after 11.3days, hence Oxema can be classified as “readily biodegradable, but failing the 10-day window”.
Reference
Description of key information
Rapid biodegradation of Oxazolidinyl ethyl methacrylate (OXEMA) was observed in a ready biodegratdation test, as it passed the criterion of 60% for demonstrating “ready biodegradability” in the manometric respirometry test. Nevertheless, the rate of biodegradation was slightly slower than that required to meet the associated 10-day window criterion. The results of this test demonstrated that oxazolidinyl ethyl methacrylate is not inhibitory of the inoculum and can be classified as “readily biodegradable, but failing the 10-day window”, according to the Introduction to Section 3 (Degradation and Accumulation) of the OECD Guidelines (OECD, 2006).
Key value for chemical safety assessment
Additional information
The aqueous hydrolysis rate constant and half-life for oxazolidinyl ethyl methacrylate (OXEMA) has been estimated using the software program HYDROWIN v1.66.
The calculated rate constant for the base-catalysed reaction (Kb) at pH>8 and at 25 degrees C was estimated to be 4.259 x x 10^-3 L/mol-sec. Half-lives at pH 7 and 8 were estimated to be 51.6 years and 5.2 years respectively.
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