Registration Dossier
Registration Dossier
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EC number: 251-718-8 | CAS number: 33885-52-8
Carcinogenicity
Administrative data
Description of key information
The genotoxicity of the substance has been assessed in vitro for three genotoxicity endpoints: genotoxicity in bacteria, cytogenicity in a chromosomal aberration assay and genemutation test in mammalian cells, resulting in the absence of genotoxicity.
Key value for chemical safety assessment
Mode of Action Analysis / Human Relevance Framework
In view of the absence of in vitro genotoxicity the substance does not have a genotoxic Mode of Action.
Justification for classification or non-classification
The genotoxicity of the substance has been assessed in vitro for three genotoxicity endpoints: genotoxicity in bacteria, cytogenicity in a chromosomal aberration assay and genemutation test in mammalian cells, resulting in the absence of genotoxicity. Therefore no genotoxic carcinogenicity is expected, via the oral, inhalation and dermal route. The substance does not need to be classified for genotoxic carcinogenicity via the oral, inhalation and dermal route in accordance with the criteria outlined in the EU CLP (EC no. 1272/2008/EC and its updates).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
