Registration Dossier
Registration Dossier
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EC number: 250-480-2 | CAS number: 31138-65-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
An ASRI study was conducted on the test material, this study was conducted according to OECD guideline 209. The results of this study showed Sodium Glucoheptonate to have an EC50 value of 1000 mg/L and a NOEC of 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
Introduction:
A study was performed to assess the effect of the test item on the respiration of activated sewage sludge. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (2010) No. 209 "Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation) ".
Methods:
Activated sewage sludge was exposed to an aqueous dispersion of the test item at concentrations of 10, 100 and 1000 mg active ingredient (ai)/L (3 replicates of the 1000 mg ai/L test concentration) for a period of 3 hours at a temperature of 20 ± 2°C with the addition of a synthetic sewage as a respiratory substrate.
The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol.
Results:
The effect of the test item on the respiration of activated sewage sludge gave a 3‑Hour EC50value of greater than 1000 mg ai/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was1000 mg ai/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg ai/L.
The reference item gave a 3-Hour EC50value of 12 mg/L, 95% confidence limits 9.6 - 15 mg/L.
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