Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Endpoint summary
Administrative data
Description of key information
skin irritation: according OECD guideline test, result: substance is corrosive
eye irritation: according OECD guideline test, result: substance is moderatly/highly irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In 2 guideline studies 3 -chloro-p-tolyl isocyanate was found corrosive or moderatly irritant to the skin.
In 2 guideline studies on eye irritation, 3-chloro-p-tolyl isocyanate was found moderately or highly irritant
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Justification for classification or non-classification
due to the results of the key study for skin irritation/corrosion R34 is justified
due to the severe effects on the eye R41 is adequate; however as the substance is labelled with R34 and additional labelling with R41 is not necessary.
Therefore for skin and eye irritation/corrosion a labelling with R34 is sufficient
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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