Registration Dossier
Registration Dossier
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EC number: 248-953-3 | CAS number: 28305-25-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
No long-term toxicity data are available for the toxicity of Calcium (S)-lactate to fish. Calcium (S)-lactate fully dissociates into Ca2+ ions and lactate. The ecotoxicology of Calcium (S)-lactate can be understood in terms of the ecotoxicology of calcium salts and lactic acid. According to REACH Annex IX, column 2, long-term toxicity testing shall be considered if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. No adverse effects of calcium chloride have been observed in the acute aquatic toxicity studies with fish, daphnids and algae at the highest recommended test concentrations of 100 mg/L. Since any effects by L-(+)-lactic acid observed in short-term aquatic toxicity tests can be attributed to pH shifts it can be concluded that the substance does not exert significant effects on environmental organisms that result in identification of a hazard. Accordingly, the chemical safety assessment does not indicate the need to further investigate environmental toxicity by means of long-term studies. Therefore, following the criteria of REACH Annex IX, point 9.1.6, column 2, and in addition for animal welfare reasons, a long-term toxicity study in fish is not considered to be required.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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