Registration Dossier
Registration Dossier
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EC number: 245-711-9 | CAS number: 23519-77-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- The target substance is hydrolytically unstable with hydrolysis half-life less than 5 minute. The hydrolysis products include 1-propanol and hydrated zirconium dioxide. The ecotoxicity data of the organic parts have been well-investigated and used for read-across.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Serum bottle test (closed system)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Test organisms (species):
- activated sludge
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 12 h
- Key result
- Duration:
- 12 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 9 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Validity criteria fulfilled:
- yes
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
- EC50 for microorganisms:
- 9 600 mg/L
Additional information
No studies were conducted on the target substance, Zirconium tetrapropanolate. As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance.
On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic (poorly soluble) zirconium dioxide and well-evaluated organic substances – 1-propanol.
The zirconium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.
Toxicity of 1-propanol to tested on activated sludge indicated EC50 (12h) of 9600 mg/l (Blum and Speece, 1991) The value was used for CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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