Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-894-7 | CAS number: 19224-26-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In a key study a fully validated QSAR prediction using EPI SuiteTM BCF Regression Method was conducted and the BCF of propylene glycol dibenzoate was determined to be 173.9 L/Kg wet-wt.
Key value for chemical safety assessment
- BCF (aquatic species):
- 173.9 L/kg ww
Additional information
A supporting QSAR was undertaken using the EPI SuiteTM Arnos and Grobas method. The prediction, fully supported with validation documents QSAR Model Reporting Format and QSAR Prediction Reporting Format document shows the BCF to be 6.7 L/Kg wet-wt.
A further supporting QSAR was performed using the TEST (Toxicity Estimation Software Tool) with the prediction being accompanied by validation and other supporting documentation produced by the software. Result from the five different QSAR methods contained within the program were in the same range as the values predicted by BCF Regression and Arnos and Grobas QSAR methods:
Hierarchical method: 11.93 - 55.46
FDA method: 2.10 - 371.09
Single model method: 0.20 - 120.85
Group contribution method: 2.94 - 340.68
Nearest neighbor method: 20.09
Giving confidence in the value predicted in the key study using the BCF Regression method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
