Registration Dossier
Registration Dossier
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EC number: 242-362-4 | CAS number: 18479-58-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Japanese government-sponsored study, stated to have been performed to GLP standard and following OECD test guideline. Linalool, a close chemical analogue of the test item with similar physico-chemical properties, was tested.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
- Remarks:
- stated to be OECD GLP standard
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.5 mg/L
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 17 mg/L
- Conclusions:
- This 21-day Daphnia reproduction study with linalool concludes a NOEC of 9.5 mg/l and an EC50 of 17 mg/l.
Reference
Results based on the test substance linalool
Description of key information
One key study was identified: this assessed the long-term toxicity of the chemical analogue linalool to Daphnia magna, in a 21-day reproduction study: a NOEC of 9.5 mg/l was determined.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.5 mg/L
Additional information
Linalool is a close chemical analogue of the test item, with similar physico-chemical properties. Results of its testing for long-term toxicity to Daphnia are therefore deemed suitable to assess the equivalent toxicity of the test item. Linalool gave a 21 -day NOEC value of 9.5 mg/l: it is reasonable to assume that dihydromyrcenol would produce a similar response in freshwater invertebrates.
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