Registration Dossier
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EC number: 235-730-0 | CAS number: 12627-14-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC0 (18h, growth inhibition) > 10000 mg/L for neutralized concentrations (pH 7.6-7.8). Equivalent to > 3480 mg active matter/L (Pseudomonas putida). RA sodium silicate
EC0 (18h, growth inhibition) > 1000 mg/L for unneutralised concentrations (pH > 9). Equivalent to > 348 mg active matter/L (Pseudomonas putida).
EC0 (30min, oxygen consumption inhibition) 3454 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 348 mg/L
Additional information
Tests with silicic acid, lithium salt are not available. Therefore, data from a related substance were considered. The toxicity of a sodium silicate solution (MR 3.46, 34.8 wt%) has been determined in a growth inhibition test in compliance with German standards and GLP using the bacterium Pseudomonas putida (Hanstveit 1989). The 18-h toxicity threshold (EC10, 10 % inhibition) of a neutralised silicate solution of pH 7.6 - 7.8 was > 3480 mg active matter/L, the highest concentration tested, while for the unneutralised solution (pH 7.9 - 10.4) effects were found at concentrations above 348 mg active matter/L. In a further GLP guideline study complying with OECD 209, the toxicity to Pseudomonas putida was tested in an oxygen consumption inhibition test. Concentrations of a sodium silicate solution (MR 3.0, 34.54 wt%) of up to 3454 mg active matter/L at pH 8.0 - 11.1 did not cause toxic effects (Kirch 1993).
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