Aluminium trititanium dodecachloride

Endpoint summary

Description of key information

The acute dermal toxicity study indicated that titanium trichloride was serious corrosive to the skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation / corrosion, other

Remarks:

Acute dermal toxicity study

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

other: OECD 402 Acute dermal toxicity

Deviations:

not specified

GLP compliance:

no

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Wako pure chemical industry Co., Ltd. 20wt% hydrochloric acid solution.

Species:

rat

Strain:

Wistar

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Japan LSC
- Age at study initiation: 11 week
- Weight at study initiation: not known
- Housing:Metal mesh cage w220 x D220 x H170 mm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24±1°C
- Humidity (%): 55 ± 5 %
- Air changes (per hr): 18 times/hr
- Photoperiod (hrs dark / hrs light):12 hrs dark/ 12 hrs light

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

other: aqueous hydrochloride solution

Controls:

no

Amount / concentration applied:

500, 1000 and 2000 mg/kg

Duration of treatment / exposure:

24 hours

Observation period:

14 days

Number of animals:

Not specified

Details on study design:

TEST SITE
- Area of exposure: back 9 x 6 cm
- % coverage: 10 % of body surface area calculated from (0.1 x body weight) ^2/3
- Type of wrap if used: aluminum foil, transparent dressing tape

REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours, applied port was washed with warm water to remove test substance completely.
- Time after start of exposure:24 hours

OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 24 hours, 2nd day, 5th day

Irritation parameter:

other: corrosive

Basis:

animal:

Time point:

24 h

Reversibility:

not reversible

Remarks on result:

probability of severe irritation

Remarks:

contact ports were seriously corroded.

Irritation parameter:

other: corrosive

Basis:

animal:

Time point:

48 h

Reversibility:

not reversible

Remarks on result:

other: change colour and eschar formation

Remarks:

Corroded port was changed its colour to brown and eschar formation began.

Irritation parameter:

other: corrosive

Basis:

animal:

Time point:

other: 5th day

Reversibility:

not reversible

Remarks on result:

other: Eschar separation

Interpretation of results:

Category 1 (corrosive) based on GHS criteria

Conclusions:

Tttanium trichloride solution was very corrosive to the skin.

Executive summary:

In the acute dermal toxicity study, this substance showed very corrosive property to the skin.

So, skin corrosion/irritation study was not carried out.

This material is corrosive to the skin.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation, other

Remarks:

In the acute dermal toxicity study, serious corrosive effect was observed.

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes

Reason / purpose for cross-reference:

reference to other study

Endpoint conclusion

Endpoint conclusion:

no study available

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

The acute dermal toxicity study indicated that titanium tirchloride was serious corrosive to skin.