Registration Dossier
Registration Dossier
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EC number: 231-784-4 | CAS number: 7727-43-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read-across BaCl2*2H2O to BaSO4:
Based on the negative results in the in-vitro tests for soluble barium compounds (BaCl2*2H2O) and assuming that poorly soluble compounds are less bioavailable, read-across from BaCl2*H2O is performed.
Short description of key
information:
in-vitro gene mutation in bacteria (OECD 471): negative
in-vitro gene mutation in mammalian cells (OECD 476): negative
in-vitro chromosome aberration (OECD 473): negative
Justification for classification or non-classification
Tests on the mutagenic potential of barium compounds in bacteria are considered dispensable for principal considerations, since inorganic metal compounds are frequently negative in this assay due to limited capacity for uptake of metal ions (Guidance on information requirements and chemical safety assessment, Chapter R.7a, p. 387; HERAG facts sheet mutagenicity, Chapter 2.1).
However, a study was made available by NTP (1994) using barium chloride as test material. Salmonella typhimurium TA97, TA 1535, TA 1537, TA 98 and TA 100 strains were used. Test concentrations fo 100, 333, 1000, 3333, 10000 µg/plate were chosen with and without metabolic activation. No increased induction of revertant colonies at all concentrations in all strains with and without metabolic activation could be observed.
It is concluded that the in vitro chromosome aberration test in CHO cells was negative with and without metabolic activation. Concentrations were tested between 50 and 5000 µg/mL.
It is concluded that barium chloride did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study. These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9).
The classification criteria according to regulation (EC) 1272/2008 as germ cell mutagen are also not met. Further testing of in vivo genetic toxicity tests is not considered necessary.
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