Registration Dossier
Registration Dossier
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EC number: 231-598-3 | CAS number: 7647-14-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 33-day NOEC value of 252 mg/L for sodium chloride was determined in a continuous flow-through exposure system with early life stage fathead minnows (Pimephales promelas).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 252 mg/L
Additional information
Two chronic freshwater fish studies using fathead minnows were examined for this endpoint. Both studies were assigned Klimish scores of 2 based on good scientific practices followed in these non-GLP, published studies. In one study, six concentrations of sodium chloride (and controls) were delivered to early life stage fathead minnows in a continuous flow-through test system for 33 days. The 33-day NOEC and LOEC based on survival were 252 and 352 mg/L sodium chloride, respectively. The 33-day NOEC and LOEC for both length and weight were 533 and 734 mg/L sodium chloride, respectively. In the other chronic toxicity test with fathead minnows, larvae (either 1, 4, or 7 days old) were exposed to concentrations of sodium chloride ranging from 1,000 to 8,000 mg/L in a semi-static exposure regime for seven days. The 7-day NOEC and LOEC based on mortality were 4,000 and 8,000 mg/L, respectively. The lowest NOEC value reported for sodium chloride was the NOEC of 252 mg/L reported in the early life stage toxicity test with fathead minnows, thus this value was selected as the key parameter for this endpoint.
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