Registration Dossier
Registration Dossier
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EC number: 230-804-9 | CAS number: 7327-60-8
Endpoint summary
Administrative data
Description of key information
Several acute oral toxicity studies were available, and several types of NTAN have been tested, viz. a standard batch, a recrystallized bath and a lab washed batch. In addition, a batch was tested with unknown purity. One dermal acute toxicity was available.
Key value for chemical safety assessment
Additional information
Although there were slight differences among six acute oral toxicity studies, viz. mortality varied between 40 to 60% at 200 mg/kg bw, it was concluded that the LD50 value was ca. 200 mg/kg bw. The batch with unknown purity showed an LD50 value between ca. 50 and ca. 200 mg/kg bw. Therefore it was concluded that the LD50 was between 50 and 200 mg/kg bw, probably close to 200 mg/kg bw. The acute dermal LD50 value was > 200 mg/kg bw (highest dose tested). Three TSCA 8(e) notifications - of which the study reports could not be obtained - showed that the acute dermal LD50 value was (1) > 794 and < 1260 mg/kg bw, (2) > 1000 mg/kg bw, and (3) > 2000 mg/kg bw. These results indicate that NTAN is much more toxic via the oral route than via the dermal route.
Justification for classification or non-classification
Because of the oral LD50 value of 50 -200 mg/kg bw; the test substance NTAN needs classification in GHS cat. III and R25 according to DSD-DPD. Based on the results described above, NTAN would need classification in GHS cat. IV and R21according to DSD-DPD for acute dermal toxicity.
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