Registration Dossier
Registration Dossier
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EC number: 227-563-7 | CAS number: 5888-87-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- deviations were considered as uncritical
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- deviations were considered as uncritical
- Principles of method if other than guideline:
- Deviations:
1) The temperature was higher than stated in the guideline. Because no mortality occured in the treatments, this deviation was stated as uncritical.
2) One fish died in the control. In the EU method, the death of one fish is regarded as acceptable. As no fish had died in all treatments, the deviation was considered as uncritical, too. - GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 22.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 22.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Test system:
Species: Danoi rerio Hamiton-Buchanan
Age: sexually immature young fish, length 1 to 3 cm
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (96 h) > 22.5 mg/L
NOEC (96 h) = 22.5 mg/L - Executive summary:
At the limit of solubility in water, the test item did not show any effect on the viability of the test system.
EC50> 22.5 mg/L, no acute aquatic hazard, category 1 classification.
Reference
Description of key information
NOEC(96h) = 22.5 mg/L
LC50(96h) > 22.5 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 22.5 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
