Registration Dossier
Registration Dossier
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EC number: 226-641-8 | CAS number: 5444-75-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BCF = 184 L/kg (BCFBAF v3.01, Arnot Gobas)
Key value for chemical safety assessment
- BCF (aquatic species):
- 184 L/kg ww
Additional information
Estimated bioconcentration (BCF) and bioaccumulation (BAF) values were calculated for all substances using the BCFBAF v3.01 program (Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10., US EPA). The substance fits within the applicability domain of the QSAR model (log Kow 0.31-8.70) and therefore, these calculations provide valid supporting information to be considered in the overall bioaccumulation assessment of this substance.
For 2-ethylhexyl benzoate, the regression based estimate results in a BCF estimation of 5810 L/kg BCF, indicating bioaccumulation potential. In contrast, BCF and BAF values, estimated using the Arnot-Gobas model, including biotransformation, results in considerable lower values (BCF: 184 L/kg and BAF: 189 L/kg). BCF calculations reflect the bioaccumulation potential after uptake via water, whereas the BAF gives an indication of the bioaccumulation when all exposure routes (water, food, etc.) are taken into account. The low BCF/BAF values calculated using the Arnot-Gobas method reflect the rapid biotransformation assumed for this substance and are considered as more reliable for the assessment of bioaccumulation of this substance, compared to the log Kow based model.
The obtained result indicates that 2-ethylhexyl benzoate is likely to show no bioaccumulation potential. According to Regulation (EC) No. 1907/2006, Annex XIII, 1.1.2, a substance only fulfils the bioaccumulation criterion (B) when BCF values are > 2000. Even though this condition is preferred to be confirmed with experimental data, in this case the estimated QSAR-based BCF/BAF values (Arnot-Gobas estimation) provide sufficient reliable evidence which suggests that 2-ethylhexyl benzoate will not be bioaccumulative.
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